🔬 Mechanism of Action

Pterosin D:
Dual PKA/PKG Activation

A novel first-in-class therapeutic mechanism targeting neuronal regeneration and cognitive enhancement through direct kinase activation.

Complete Mechanism: From Intake to Action

Interactive Journey - Hover over components to learn more

Oral Intake 1 mg/kg/day GI Absorption BA: 27.4% Bloodstream Blood Brain BBB Crossing High Permeability Brain Entry 🧠 CORTICAL NEURON (Cerebral Cortex) Cell Membrane Nucleus Pterosin D EC₅₀ = 25 pM Direct Activation Direct Activation ATP PKA Protein Kinase A GTP PKG Protein Kinase G Phosphorylation Phosphorylation P p-CREB Transcription Factor Gene Expression ↑ BDNF ↑ Neurotrophic Factor (27 kDa) Secretion BDNF TrkB Receptor Therapeutic Outcomes: ✓ LTP Enhancement ✓ Memory Improvement ✓ Neurite Outgrowth ✓ Neurogenesis ✓ Synaptic Plasticity
Pterosin D
PKA Pathway
PKG Pathway
CREB
BDNF
TrkB
🎯

Novel Mechanism

Direct PKA/PKG activation without PDE inhibition. Bypasses cAMP/cGMP pathways.
ECâ‚…â‚€ = 25 pM

🧠

Neuron-Selective

Activates CREB in cerebral cortex neurons. No activation in astrocytes, minimizing side effects.

🔬

Therapeutic Effects

Promotes LTP, neurite outgrowth, and neuronal proliferation & differentiation.

💊

Drug Properties

High BBB permeability.
Bioavailability 27.4%

Preclinical Results (5xFAD AD Mouse Model)

100%
Cognitive Recovery
Morris Water Maze Test
1
mg/kg/day
Oral Administration
12
Weeks
Treatment Duration
✓
Memory Enhancement
LTP in Hippocampus